
Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist
Semaglutide and Tirzepatide are highly effective medications for managing obesity and supporting weight loss. They work by mimicking natural hormones—GLP-1, and in the case of Tirzepatide, both GLP-1 and GIP—that help regulate appetite, blood sugar, and metabolism.
Benefits
Significant weight loss
Improved blood sugar control
Enhanced insulin sensitivity
Reduced cardiovascular risk (Semaglutide)
Greater weight loss and glucose control with dual-action (Tirzepatide)
Potential Side Effects
Nausea, vomiting, diarrhea, or constipation (most common when starting treatment)
Possible increased risk of pancreatitis
FDA boxed warning for thyroid tumors (seen in animal studies, not humans)
Safety Considerations
These medications may not be appropriate for people with a history of:
Pancreatitis
Certain thyroid cancers (including medullary thyroid carcinoma)
Before starting therapy, it’s important to discuss your medical history and goals with a qualified provider to determine if GLP-1 or GIP medications are the right fit for you.